Cause of a major paradigm shift, and an apt description of 17-, 25-, 37-, and 51-Across as well as their sets of circled letters Crossword Clue

Based on our findings the most likely answer to the Cause of a major paradigm shift, and an apt description of 17-, 25-, 37-, and 51-Across as well as their sets of circled letters crossword clue is: gamechanger

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